Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation

We investigated how gene expression of CD4 T cells changes in a time course of activation and how it is influenced by the donor genotypes. We profiled more than 600K naive and memory T cells from 119 donors, localised them on the trajectory of activation and identified cell-subtype specific and timepoint-specific eQTLs.

Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation. Read paper

Soskic, Blagoje, Cano-Gamez, Eddie, Smyth, Deborah J., Ambridge, Kirsty, Ke, Ziying, Bossini-Castillo, Lara, Kaplanis, Joanna, Ramirez-Navarro, Lucia, Nakic, Nikolina, Esparza-Gordillo, Jorge, Rowan, Wendy, Wille, Dawid, Tough, David F., Bronson, Paola G., & Trynka, Gosia. Nat Genet (2022).

Raw data eQTLs identified in this dataset Trynka group